Fibrodysplasia ossificans progressive (FOP)

Fibrodysplasia ossificans progressive (FOP) is a connective tissue disorder that is genetic in nature. It’s a rare condition. In this condition, ligaments, tendons and muscles become tough fibrous tissues that may even then become calcified as bone. It happens when there’s an injury to the tissue. The only symptom of the disease is a big toe that is malformed when a baby is born. Cause The cause is thought to be genetic. Treatment and Prevention At this time there is no known treatment for this disease. Surgery is essentially another “injury” to the foot and causes more fibrous tissue to be produced, and more bone formation. However, palliative measures may be used to reduce the suffering and pain from the condition. For example, orthotic inserts or sensitive feet insoles can at least reduce the pressure on the foot at different locations.