Blue toe syndrome is a condition where the toes turn blue because of a blood clot that is occurring somewhere in the body, usually in the toe, foot, leg, or even the heart. Cause When the toes turn blue, this can be caused by a number of things. However, the Blue Toe Syndrome is most commonly caused by an embolism. Here are some other causes of blue toe syndrome: • high levels of white blood cells, platelets and immunoglobulins • inflammation of the blood vessels • spasm of the blood vessels such as in Raynaud’s phenomenon and Pernio • systemic lupus erythematosus • essential thrombocytopenia • frostbite of the toes • medication side effects (Warfarin, steroids) • illegal drugs such as amphetamine and cocaine The most common reason for the Blue Toe Syndrome is a blood clot. Treatment and Prevention Medical treatment is important and varies depending on the cause. Warfarin, an anticoagulant, is prescribed which clears the blood of clots, if the cause is an embolism. However, it won’t work if the blue toes are caused by Warfarin. If the blue toe syndrome has occurred because of illegal drug use, the drugs need to be stopped. If it’s a result of SLE or thrombocytopenia, or other medical condition, the blue toes should resolve when the medical conditions are addressed.